Development of a comprehensive noninvasive prenatal test
نویسندگان
چکیده
منابع مشابه
Whole genome sequencing based noninvasive prenatal test
NIFTY test by BGI detects trisomies 13, 18, and 21 as well as some sex chromosome aneuploidies and selected microdeletions [3]. Verinata Health, a subsidiary of Illumina offers the Verifi test for detection of trisomies 13, 18, 21, and the presence of monosomy X. The expanded version of this test also detects other aneuploidies and microdeletions [4]. Compared to other NIPT techniques such as t...
متن کاملDetection of contamination in noninvasive prenatal fetal gender test
The risk of false positive results in noninvasive prenatal diagnosis focused on fetal gender and RhD status determination could be a problem in clinical routine. This is because these tests are based on detection of presence of DNA sequences with high population frequency and so there is the risk of sample contamination during sample collection and processing. In our study the different fragmen...
متن کاملAdvantages of the single nucleotide polymorphism- based noninvasive prenatal test
the placenta into the maternal circulation as the cells break down (apoptosis) and the DNA becomes fragmented [4,5]. Circulating fetal cfDNA comprises approximately 3-13% of the total maternal cfDNA. These DNA fragments can be detected as early as 4 weeks of gestation and are generally cleared out within 2 hours after childbirth [6-8]. A noninvasive prenatal test (NIPT) using cfDNA has proven t...
متن کاملA new era in noninvasive prenatal testing.
499 developing world, might help to encourage companies to spend resources on breakthrough innovation, rather than on minor modifications and lawyer fees. But whatever its implications for innovation, this much is clear: poor people around the world need better access to affordable drugs, and this decision will help to provide it. Disclosure forms provided by the author are available with the f...
متن کاملNoninvasive prenatal diagnosis of duchenne muscular dystrophy: comprehensive genetic diagnosis in carrier, proband, and fetus.
BACKGROUND Noninvasive prenatal diagnosis of monogenic disorders using maternal plasma and targeted massively parallel sequencing is being investigated actively. We previously demonstrated that comprehensive genetic diagnosis of a Duchenne muscular dystrophy (DMD) patient is feasible using a single targeted sequencing platform. Here we demonstrate the applicability of this approach to carrier d...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genetics and Molecular Biology
سال: 2018
ISSN: 1678-4685,1415-4757
DOI: 10.1590/1678-4685-gmb-2017-0177